globalchange  > 气候变化与战略
DOI: 10.1073/pnas.2004262117
论文题名:
EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila
作者: Abrieux A.; Xue Y.; Cai Y.; Lewald K.M.; Nguyen H.N.; Zhang Y.; Chiu J.C.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期:26
起始页码: 15293
结束页码: 15304
语种: 英语
英文关键词: Alternative Splicing ; Circadian Clock ; photoperiod ; Seasonality ; Temperature
Scopus关键词: isoprotein ; protein EYA ; protein timeless ; transcription factor CLOCK ; unclassified drug ; Drosophila protein ; eya protein, Drosophila ; eye protein ; tim protein, Drosophila ; adult ; animal experiment ; Article ; circadian rhythm ; cold sensation ; controlled study ; Diptera ; dormancy ; Drosophila melanogaster ; female ; female genital system ; genetic manipulation ; light ; night ; nonhuman ; photoperiodicity ; priority journal ; protein expression ; protein stability ; protein synthesis ; seasonal variation ; temperature sense ; tissue specificity ; winter ; animal ; Drosophila melanogaster ; gene expression regulation ; genetics ; metabolism ; physiology ; reproduction ; season ; temperature ; Animals ; Drosophila melanogaster ; Drosophila Proteins ; Eye Proteins ; Gene Expression Regulation ; Photoperiod ; Reproduction ; Seasons ; Temperature
英文摘要: Organisms possess photoperiodic timing mechanisms to detect variations in day length and temperature as the seasons progress. The nature of the molecular mechanisms interpreting and signaling these environmental changes to elicit downstream neuroendocrine and physiological responses are just starting to emerge. Here, we demonstrate that, in Drosophila melanogaster, EYES ABSENT (EYA) acts as a seasonal sensor by interpreting photoperiodic and temperature changes to trigger appropriate physiological responses. We observed that tissue-specific genetic manipulation of eya expression is sufficient to disrupt the ability of flies to sense seasonal cues, thereby altering the extent of female reproductive dormancy. Specifically, we observed that EYA proteins, which peak at night in short photoperiod and accumulate at higher levels in the cold, promote reproductive dormancy in female D. melanogaster. Furthermore, we provide evidence indicating that the role of EYA in photoperiodism and temperature sensing is aided by the stabilizing action of the light-sensitive circadian clock protein TIMELESS (TIM). We postulate that increased stability and level of TIM at night under short photoperiod together with the production of cold-induced and light-insensitive TIM isoforms facilitate EYA accumulation in winter conditions. This is supported by our observations that tim null mutants exhibit reduced incidence of reproductive dormancy in simulated winter conditions, while flies overexpressing tim show an increased incidence of reproductive dormancy even in long photoperiod. © 2020 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163452
Appears in Collections:气候变化与战略

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作者单位: Abrieux, A., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Xue, Y., Department of Biology, University of Nevada Reno, Reno, NV 89557, United States; Cai, Y., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Lewald, K.M., Department of Biology, University of Nevada Reno, Reno, NV 89557, United States; Nguyen, H.N., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Zhang, Y., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States; Chiu, J.C., Department of Entomology and Nematology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, United States

Recommended Citation:
Abrieux A.,Xue Y.,Cai Y.,et al. EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(26)
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