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DOI:	10.1371/journal.pone.0085374
论文题名:	Two-Step Source Tracing Strategy of Yersinia pestis and Its Historical Epidemiology in a Specific Region
作者:	Yanfeng Yan; Hu Wang; Dongfang Li; Xianwei Yang; Zuyun Wang; Zhizhen Qi; Qingwen Zhang; Baizhong Cui; Zhaobiao Guo; Chang Yu; Jun Wang; Jian Wang; Guangming Liu; Yajun Song; Yingrui Li; Yujun Cui; Ruifu Yang
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-1-9
卷:	9, 期:1
语种:	英语
英文关键词:	Yersinia pestis ; Comparative genomics ; Plagues ; Phylogenetic analysis ; Phylogenetics ; Sequence analysis ; Genome analysis ; Phylogeography
英文摘要:	Source tracing of pathogens is critical for the control and prevention of infectious diseases. Genome sequencing by high throughput technologies is currently feasible and popular, leading to the burst of deciphered bacterial genome sequences. Utilizing the flooding genomic data for source tracing of pathogens in outbreaks is promising, and challenging as well. Here, we employed Yersinia pestis genomes from a plague outbreak at Xinghai county of China in 2009 as an example, to develop a simple two-step strategy for rapid source tracing of the outbreak. The first step was to define the phylogenetic position of the outbreak strains in a whole species tree, and the next step was to provide a detailed relationship across the outbreak strains and their suspected relatives. Through this strategy, we observed that the Xinghai plague outbreak was caused by Y. pestis that circulated in the local plague focus, where the majority of historical plague epidemics in the Qinghai-Tibet Plateau may originate from. The analytical strategy developed here will be of great help in fighting against the outbreaks of emerging infectious diseases, by pinpointing the source of pathogens rapidly with genomic epidemiological data and microbial forensics information.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085374&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19265
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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作者单位:

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;BGI-Shenzhen, Shenzhen, China;Qinghai Institute for Endemic Diseases Prevention and Control, Xining, China;BGI-Shenzhen, Shenzhen, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;Qinghai Institute for Endemic Diseases Prevention and Control, Xining, China;Qinghai Institute for Endemic Diseases Prevention and Control, Xining, China;Qinghai Institute for Endemic Diseases Prevention and Control, Xining, China;Qinghai Institute for Endemic Diseases Prevention and Control, Xining, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;BGI-Shenzhen, Shenzhen, China;BGI-Shenzhen, Shenzhen, China;BGI-Shenzhen, Shenzhen, China;School of Computer Science, National University of Defense Technology, Changsha, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;BGI-Shenzhen, Shenzhen, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;BGI-Shenzhen, Shenzhen, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;BGI-Shenzhen, Shenzhen, China

Recommended Citation:

Yanfeng Yan,Hu Wang,Dongfang Li,et al. Two-Step Source Tracing Strategy of Yersinia pestis and Its Historical Epidemiology in a Specific Region[J]. PLOS ONE,2014-01-01,9(1)

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