Objectives This study was conducted to generate knowledge useful for developing public health interventions for more effective tuberculosis control in Arkansas. Methods The study population included 429 culture-confirmed reported cases (January 1, 2004–December 31, 2010). Mycobacterium tuberculosis genotyping data were used to identify cases likely due to recent transmission (clustered) versus reactivation (non-clustered). Poisson regression models estimated average decline rate in incidence over time and assessed the significance of differences between subpopulations. A multinomial logistic model examined differences between clustered and non-clustered incidence. Results A significant average annual percent decline was found for the overall incidence of culture-confirmed (9%; 95% CI: 5.5%, 16.9%), clustered (6%; 95% CI: 0.5%, 11.6%), and non-clustered tuberculosis cases (12%; 95% CI: 7.6%, 15.9%). However, declines varied among demographic groups. Significant declines in clustered incidence were only observed in males, non-Hispanic blacks, 65 years and older, and the rural population. Conclusions These findings suggest that the Arkansas tuberculosis control program must target both traditional and non-traditional risk groups for successful tuberculosis elimination. The present study also demonstrates that a thorough analysis of TB trends in different population subgroups of a given geographic region or state can lead to the identification of non-traditional risk factors for TB transmission. Similar studies in other low incidence populations would provide beneficial data for how to control and eventually eliminate TB in the U.S.
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America;Arkansas Department of Health, Little Rock, Arkansas, United States of America;Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America;Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America;Arkansas Department of Health, Little Rock, Arkansas, United States of America;Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America;Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America;Arkansas Department of Health, Little Rock, Arkansas, United States of America;College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America;Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America
Recommended Citation:
Anna Berzkalns,Joseph Bates,Wen Ye,et al. The Road to Tuberculosis (Mycobacterium tuberculosis) Elimination in Arkansas; a Re-Examination of Risk Groups[J]. PLOS ONE,2014-01-01,9(3)