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DOI:	10.1371/journal.pone.0136074
论文题名:	Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada
作者:	Carla Osiowy; Elizabeth Giles; Max Trubnikov; Yogesh Choudhri; Anton Andonov
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-9-25
卷:	10, 期:9
语种:	英语
英文关键词:	DNA sequence analysis ; Sequence analysis ; Canada ; Hepatitis B virus ; Sequence alignment ; Phylogenetic analysis ; Amino acid sequence analysis ; Phylogeography
英文摘要:	Objective The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding of HBV strain distribution and transmission risk. Methods HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submitted for strain analysis or reference genotype testing between 2006 and 2012 were analyzed. The HBsAg coding region was amplified to determine the HBV genotype by INNO-LiPA assay or sequence analysis. Single and multivariate analyses were used to describe genotypes’ associations with known demographic and behavioral risk factors for 126 linked cases of acute HBV. Results Nine genotypes were detected (A to I), including mixed infections. Genotype C (HBV/C) dominated within chronic infections while HBV/D and A prevailed among acute HBV cases. History of incarceration and residing with a chronic HBV carrier or injection drug user were the most frequently reported risks for acute HBV infection. Over time, HBV/A increased among both acute and chronic infections, and HBV/C and HBV/D decreased among chronic infections. Conclusion Chronic and acute HBV genotypes in Canada differ in the relative distribution and their associations with known risk factors, suggesting different routes of transmission and clinical progression of infection.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0136074&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/21509
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0136074.PDF（607KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada;National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada;Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada;Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada;National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

Recommended Citation:

Carla Osiowy,Elizabeth Giles,Max Trubnikov,et al. Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada[J]. PLOS ONE,2015-01-01,10(9)

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