DOI: 10.1111/gcb.12219
论文题名: Changes in atmospheric CO2 influence the allergenicity of Aspergillus fumigatus
作者: Lang-Yona N. ; Levin Y. ; Dannemiller K.C. ; Yarden O. ; Peccia J. ; Rudich Y.
刊名: Global Change Biology
ISSN: 13541013
出版年: 2013
卷: 19, 期: 8 起始页码: 2381
结束页码: 2388
语种: 英语
英文关键词: Allergenic potency
; Allergens
; Aspergillus fumigatus
; Climate change
; Environmental allergens
Scopus关键词: atmospheric deposition
; carbon dioxide
; climate change
; concentration (composition)
; environmental conditions
; fungus
; growth
; nitrogen
; particulate matter
; Aspergillus fumigatus
; Fungi
; allergen
; ASPF1 protein, Aspergillus fumigatus
; carbon
; carbon dioxide
; fungal protein
; fungus antibody
; immunoglobulin E
; monoclonal antibody
; nitrogen
; allergenic potency
; article
; Aspergillus fumigatus
; climate change
; environmental allergens
; fungus spore
; gene expression regulation
; genetics
; growth, development and aging
; human
; immunology
; liquid chromatography
; mass spectrometry
; metabolism
; real time polymerase chain reaction
; allergenic potency
; allergens
; Aspergillus fumigatus
; climate change
; environmental allergens
; Allergens
; Antibodies, Fungal
; Antibodies, Monoclonal
; Aspergillus fumigatus
; Carbon
; Carbon Dioxide
; Chromatography, Liquid
; Climate Change
; Fungal Proteins
; Gene Expression Regulation
; Humans
; Immunoglobulin E
; Mass Spectrometry
; Nitrogen
; Real-Time Polymerase Chain Reaction
; Spores, Fungal
英文摘要: Increased susceptibility to allergies has been documented in the Western world in recent decades. However, a comprehensive understanding of its causes is not yet available. It is therefore essential to understand trends and mechanisms of allergy-inducing agents, such as fungal conidia. In this study, we investigated the hypothesis that environmental conditions linked to global atmospheric changes can affect the allergenicity of Aspergillus fumigatus, a common allergenic fungal species in indoor and outdoor environments and in airborne particulate matter. We show that fungi grown under present-day CO2 levels (392 ppm) exhibit 8.5 and 3.5 fold higher allergenicity compared to fungi grown at preindustrial (280 ppm) and double (560 ppm) CO2 levels, respectively. A corresponding trend is observed in the expression of genes encoding for known allergenic proteins and in the major allergen Asp f1 concentrations, possibly due to physiological changes such as respiration rates and the nitrogen content of the fungus, influenced by the CO2 concentrations. Increased carbon and nitrogen levels in the growth medium also lead to a significant increase in the allergenicity. We propose that climatic changes such as increasing atmospheric CO2 levels and changes in the fungal growth medium may impact the ability of allergenic fungi such as A. fumigatus to induce allergies. © 2013 John Wiley & Sons Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/62386
Appears in Collections: 影响、适应和脆弱性
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作者单位: Department of Environmental Sciences, Weizmann Institute of Science, Rehovot 76100, Israel; Proteomics and Mass Spectrometry Unit, Weizmann Institute of Science, Rehovot 76100, Israel; Mason Laboratory, Department of Chemical and Environmental Engineering, Yale University, 9 Hillhouse Avenue, New Haven, CT 06520-8286, United States; Department of Plant Pathology and Microbiology, R.H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Rehovot 76100, Israel
Recommended Citation:
Lang-Yona N.,Levin Y.,Dannemiller K.C.,et al. Changes in atmospheric CO2 influence the allergenicity of Aspergillus fumigatus[J]. Global Change Biology,2013-01-01,19(8)