DOI: 10.1016/j.marpolbul.2016.04.063
Scopus记录号: 2-s2.0-84971247445
论文题名: Assessment of the environmental quality of coastal sediments by using a combination of in vitro bioassays
作者: Pérez-Albaladejo E. ; Rizzi J. ; Fernandes D. ; Lille-Langøy R. ; Karlsen O.A. ; Goksøyr A. ; Oros A. ; Spagnoli F. ; Porte C.
刊名: Marine Pollution Bulletin
ISSN: 0025-326X
EISSN: 1879-3363
出版年: 2016
卷: 108, 期: 2018-01-02 起始页码: 53
结束页码: 61
语种: 英语
英文关键词: Biomonitoring
; CYP1A induction
; Cytotoxicity
; PLHC-1 cells
; PXR agonists
; Sediments
Scopus关键词: Aquatic organisms
; Chemical activation
; Cytotoxicity
; Submarine geology
; Biomonitoring
; Coastal sediments
; CYP1A induction
; Environmental quality
; Marine sediments
; PXR agonists
; Sediment extracts
; Subcellular fractions
; Sediments
; aromatase
; cytochrome P450 1A
; dioxin
; hydrocarbon
; lindane
; reactive oxygen metabolite
; water pollutant
; bioassay
; biomonitoring
; coastal sediment
; environmental assessment
; environmental quality
; toxicity
; aquatic species
; Article
; bioassay
; cell fractionation
; coastal waters
; controlled study
; COS 7 cell line
; cytotoxicity
; enzyme activation
; enzyme activity
; enzyme inhibition
; European sea bass
; in vitro study
; nonhuman
; oxidative stress
; river
; sediment
; urban area
; zebra fish
; animal
; Black Sea
; environmental monitoring
; Italy
; Romania
; water pollutant
; Danube River
; Italy
; Po River
; Danio rerio
; Serranidae
; Animals
; Biological Assay
; Black Sea
; Environmental Monitoring
; Geologic Sediments
; Italy
; Rivers
; Romania
; Water Pollutants, Chemical
Scopus学科分类: Agricultural and Biological Sciences: Aquatic Science
; Earth and Planetary Sciences: Oceanography
; Environmental Science: Pollution
英文摘要: The environmental quality of marine sediments collected in the area of influence of the Po and Danube Rivers was assessed by using a battery of bioassays based on the use of PLHC-1 cells, zebrafish-Pxr-transfected COS-7 cells, and sea bass ovarian subcellular fractions. This allowed the determination of multiple endpoints, namely, cytotoxicity, oxidative stress, induction of CYP1A, activation of zebrafish Pxr and inhibition of ovarian aromatase. Organic extracts of sediments influenced by the Danube River and collected near harbors and urban discharges showed significant cytotoxicity, CYP1A induction and inhibition of aromatase activity. An analogous response of CYP1A induction and zfPxr activation was observed, which suggests the existence of common ligands of AhR and PXR in the sediment extracts. The study highlights the usefulness of the selected bioassays to identify those sediments that could pose a risk to aquatic organisms and that require further action in order to improve their environmental quality. © 2016 Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/86971
Appears in Collections: 过去全球变化的重建 全球变化的国际研究计划
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作者单位: Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain; Department of Hydraulics and Sanitation, Federal University of Parana, Curitiba, Brazil; Department of Biology, University of Bergen, Norway; National Inst. for Marine Research and Development 'Grigore Antipa', Constanta, Romania; Institute of Marine Sciences, National Research council, ISMAR-CNR, Italy
Recommended Citation:
Pérez-Albaladejo E.,Rizzi J.,Fernandes D.,et al. Assessment of the environmental quality of coastal sediments by using a combination of in vitro bioassays[J]. Marine Pollution Bulletin,2016-01-01,108(2018-01-02)