| 项目编号: | 1512764
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| 项目名称: | UNS: Engineering Infection-Free Implants for Skeletal Reconstruction |
| 作者: | Huinan Liu
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| 承担单位: | University of California-Riverside
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| 批准年: | 2014
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| 开始日期: | 2015-10-01
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| 结束日期: | 2018-12-31
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| 资助金额: | USD365565
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | infection
; research
; magnesium alloy
; engineering challenge
; engineering solution
; project
; engineering day
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| 英文摘要: | More than 50 million people per year worldwide need synthetic implants to help recover from bone loss or injury resulting from trauma or disease. This project seeks to develop a new class of materials that, for the first time, has all of the properties of an ideal implant: it should support body weight and mechanical stress, suppress infection, enhance bone healing, and ultimately dissolve harmlessly as bone tissue grows back. While more than 100 synthetic bone grafts are approved for clinical use, none of them has all of these properties. This research not only addresses the challenges in treating critical-sized large bone defects to restore mobility and independent life of patients, but also significantly reduces the clinical dependence on antibiotics and expensive growth factors, thus reducing associated side effects (e.g., antibiotic resistance) and health care costs. The outcome of this research will lead to the next-generation implants that have the combined advantages of current metallic and polymeric implants while eliminating their problems. More broadly, this project will open up new avenues of research in smart resorbable materials, build the foundation for practical design guidelines, benefit millions of patients with skeletal injuries or diseases, and attract significant interests of implant industry for technology transfer. These, in turn, will increase the competitiveness of U.S. companies in the global medical device market. The integrated research and education plans will also have broader impacts on graduate, undergraduate, and pre-college education as well as public awareness about engineering solutions that benefit health care. In collaboration with the existing programs at the University of California, Riverside, the Principal Investigator will attract underrepresented minority students and students with disabilities, motivate pre-college students through fun biomaterial modules with ALPHA center and MESA Schools Programs, and educate the public through collaborative events with Bourns Science and Engineering Day.
The overall objective of this project is to engineer a novel resorbable antibacterial osteoinductive implant (RAOI) that will bear weight and resist bending and torsion. Specifically, the RAOI consists of bioresorbable, biocompatible and mechanically strong magnesium alloys as the bulk substrate and engineered nanostructures on the surface to prevent infection and enhance bone regeneration. The novelty of RAOI design lies in its integrated multifunctionality that can potentially meet ALL criteria for an ideal implant for the first time. To unlock the full potential of magnesium alloys, we must address the critical scientific and engineering challenge of controlling their degradation rate. Our novel approach is to create engineered nanostructures on the surface of magnesium alloys to achieve the three key functions simultaneously: (1) modulate degradation rate of bulk magnesium substrates, (2) reduce adhesion and viability of pathogenic bacteria, and (3) enhance adhesion and osteogenic differentiation of bone marrow derived mesenchymal stem cells for faster bone healing. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/93161
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Huinan Liu. UNS: Engineering Infection-Free Implants for Skeletal Reconstruction. 2014-01-01.
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