| 项目编号: | 1354890
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| 项目名称: | RCN: Infectious Disease Evolution Across Scales |
| 作者: | Andrea Graham
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| 承担单位: | Princeton University
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| 批准年: | 2013
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| 开始日期: | 2014-07-01
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| 结束日期: | 2019-06-30
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| 资助金额: | USD400187
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| 资助来源: | US-NSF
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| 项目类别: | Continuing grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | pathogen evolution
; pathogen
; evolutionary biologist
; different biological scale
; disease occurrence
; evolution-proof medical treatment
; network
; evolutionary pressure
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| 英文摘要: | This Research Coordination Network will investigate pathogens across scales of biological organization with the goal of better understanding of the processes that determine pathogen transmission and disease occurrence. Why do pathogens, even different strains within a species, differ so dramatically in the severity of disease induced in a host? And why do pathogens vary in efficiency of transmission from one host to the next? These questions focus on different biological scales (the host organism versus the host population) yet are inextricably connected in determining evolutionary pressures on pathogens: persistence of a strain is jointly determined by exploitation of individual hosts and by transmission across the host population. Network activities will build collaborations among microbiologists, immunologists, epidemiologists and evolutionary biologists via workshops and research exchanges. Network members will develop data and tools to: a) identify causes of variation among strains of important pathogens; b) predict pathogen evolution in diverse immunological and epidemiological contexts; and c) design medical interventions to minimize chances of pathogen evolution rendering drugs or vaccines obsolete.
This project will bring benefits to multiple stakeholders. For researchers, the Network will provide a database with linked analytical tools, plus ample training opportunities. For students of biology, mathematics and medicine, the Network will generate teaching modules that convey interdisciplinary skills and insights. Finally, the Network will promote the development of evolution-proof medical treatments. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96557
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Andrea Graham. RCN: Infectious Disease Evolution Across Scales. 2013-01-01.
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